Adrenoleukodystrophy is a genetically conditioned, hereditary degenerative disease of the brain, associated with an insufficient function of the adrenal glands.

Addison's disease is considered a fairly rare disease of the endocrine system, which accompanies the chronic insufficiency of the adrenal cortex as a result of its one-sided and bilateral lesions.

The essence of Addison's disease is an autoimmune process, that is, the body is attacked by its own immune cells, destroying once-established immunity and not only. However, other pathogenic factors also stand out:
- Tuberculosis of the adrenal glands;
- Syphilis;
- Extensive fungal lesions;
- Bleeding in the adrenal glands;
- AIDS;
- Adrenoleukodystrophy;
- Removal of the adrenal glands;
- Sarcoidosis;
- Long-term drug therapy of individual pharmacological groups.